When should I call 911 on a GLP-1?
Call 911 on Wegovy, Ozempic (semaglutide), Zepbound or Mounjaro (tirzepatide) for signs of a severe allergic reaction, such as a swelling face, lips or throat or trouble breathing, and for severe stomach pain, vomiting blood, fainting or chest pain. If you have taken too much, call Poison Control on 1-800-222-1222.
Which symptoms mean you should call 911?
Call 911 for a severe allergic reaction, and for the emergency warning signs on US emergency doctors’ list, such as severe stomach pain or vomiting blood.1,2,3
The US Medication Guides for Wegovy and Zepbound say to stop the medicine and “get medical help right away” for a serious allergic reaction.1,2 They say severe stomach pain that won’t go away, sometimes felt through to the back, can be pancreatitis.1,2
- swelling of your face, lips, tongue or throat, problems breathing or swallowing, or a very rapid heartbeat1,2
- fainting, feeling faint, or someone who collapses or can’t be woken2,3,4
- severe stomach pain or pressure that won’t go away1,3
- vomiting or coughing up blood, or severe or persistent vomiting or diarrhea3
- chest pain or discomfort lasting 2 minutes or more3
- sudden confusion, unusual behavior or difficulty waking3
- sudden dizziness, weakness or change in vision3
When should you call your doctor instead?
Call your prescriber promptly for problems that are serious but not life-threatening right now, as the Medication Guides list them.1,2
- nausea, vomiting or diarrhea that doesn’t go away, since losing fluids can harm the kidneys1
- gallbladder signs: pain in the upper stomach, yellow skin or eyes, fever, or clay-colored stools1
- a racing or pounding heart at rest that lasts several minutes1
- signs of low blood sugar, such as shakiness, sweating or confusion, if you also take insulin or a sulfonylurea1
- changes in vision if you have type 2 diabetes1
If a symptom gets worse fast, treat it as an emergency. Everyday side effects are in Guide 5.
What if you took too much?
Taking too much can cause severe nausea, severe vomiting and severe low blood sugar, the Wegovy Medication Guide says.1
Both Medication Guides say to call your healthcare provider or the Poison Help line on 1-800-222-1222, or go to the nearest emergency room right away.1,2 Poison Control is “free, expert, and confidential.”4
Dosing mistakes have happened with compounded semaglutide: the FDA has reports of side effects, “some requiring hospitalization,” that may be linked to them.6 Once you are safe, you can report what happened: see How do I report a side effect to the FDA?
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Related questions
Sources
- Novo Nordisk. Wegovy (semaglutide) injection and tablets, US prescribing information and Medication Guide, revised 06/2026. US label. novo-pi.com
- Eli Lilly. Zepbound (tirzepatide) US prescribing information, Medication Guide and Instructions for Use, revised 08/2026. US label. uspl.lilly.com
- MedlinePlus (US National Library of Medicine). Recognizing medical emergencies (warning signs from the American College of Emergency Physicians). Reviewed Jan 8, 2025. medlineplus.gov
- Poison Control (National Capital Poison Center). “Call a poison center at 1-800-222-1222… free, expert, and confidential”; call 911 if someone “collapses, has a seizure, has trouble breathing or can’t be awakened”. poison.org
- 988 Suicide & Crisis Lifeline: call, text or chat 988, “available 24/7/365”, “free and confidential”. 988lifeline.org
- FDA. FDA’s concerns with unapproved GLP-1 drugs used for weight loss. Content current as of Oct 1, 2026 (adverse-event counts as of May 31, 2026). fda.gov
Last checked Oct 12, 2026 · Next review due Oct 12, 2027 · Report an error
How this answer was made. Written by the GLP Guidebook team from the sources above, all checked on Oct 12, 2026. It’s general information, not medical advice. Talk to a doctor, pharmacist or other licensed prescriber before starting, stopping or changing any medicine. In an emergency, call 911. How we write